Anti-MRP4 antibody [M4I-80]
| Name | Anti-MRP4 antibody [M4I-80] |
|---|---|
| Supplier | Abcam |
| Catalog | ab15598 |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone | M4I-80 |
| Applications | IHC-P ICC/IF IHC-F WB |
| Species Reactivities | Mouse, Human |
| Antigen | Fusion protein: AIERVSEAIV SIRRIQTFLL LDEISQRNRQ LPSDGKKMVH VQDFTAFWDK ASETPTLQGL , corresponding to amino acids 372-431 of Human MRP4 and E |
| Description | Rat Monoclonal |
| Gene | ABCC4 |
| Conjugate | Unconjugated |
| Supplier Page | Shop |
Product images
IHC image of ab15598 staining in human normal kidney formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab15598, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
Product References
Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. - Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS. FASEB J. 2012 Mar;26(3):1009-17.
Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice. - Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice.
Hara Y, Sassi Y, Guibert C, Gambaryan N, Dorfmuller P, Eddahibi S, Lompre AM, Humbert M, Hulot JS. J Clin Invest. 2011 Jul;121(7):2888-97.