AZD8055, Free Base

• Supplier: Biorbyt
• Catalog: orb153601
• Prices: $247.00, $281.00, $349.00, $383.00, $485.00, $706.00
• Sizes: 5 mg, 10 mg, 50 mg, 25 mg, 100 mg, 200 mg
• Cas Number: [1009298-09-2]
• Pubchem: 25262965
• Chemical Name: [5-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• Formula: C25H31N5O4
• Molecular Weight: 465.54 g/mol
• Purity: >99% pure
• Description: AZD8055 is also named as[CCG-168]. AZD8055 is a novel ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR) kinase with an IC50 value of 0. 8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, mTORC2 substrate AKT, and downstream proteins. AZD8055 also blocked the chemotherapy-induced cell death promoted by ectopic wild-type p62. AZD8055 potently inhibits proliferation, induces autophagy and apoptosis in different cells. Up to 10 μM AZD8055 showed no significant activity against a panel of 260 kinases at concentrations.