Linsitinib, Free Base

• Supplier: Biorbyt
• Catalog: orb153620
• Prices: $306.00, $340.00, $383.00, $493.00, $629.00, $952.00, $1,216.00, $1,641.00
• Sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 500 mg
• Cas Number: [867160-71-2]
• Pubchem: 11640390
• Chemical Name: 3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol
• Formula: C26H23N5O
• Molecular Weight: 421.49 g/mol
• Purity: >99% pure
• Description: Linsitinib, Free Base. Linsitinib is also known as OSI-906, is a novel, potent small-molecule dual insulin-like growth factor-1 receptor (IGF-1R)/insulin receptor (IR) kinase inhibitor. Linsitinib inhibited IGF-1R and IR kinases with IC50 values of 35 nM and 75 nM, respectively. Linsitinib showed superior efficacy compared with MAB391, a selective anti-IGF-1R antibody, in human tumor xenograft models in which both IGF-1R and IR were phosphorylated.