DNA Methyltransferase Inhibitor II, SGI-1027 - Calbiochem
| Name | DNA Methyltransferase Inhibitor II, SGI-1027 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 260921 |
| Formula | C₂₇H₂₃N₇O |
| Purity | ≥88% by HPLC |
| Description | A cell-permeable quinoline compound that is shown to inhibit human DNMT1 (IC 50 = 6 and 12.5 µM, respectively, with Hemimethylated DNA or Poly(dI-dC) as the substrate), murine DNMT3a & 3b (IC 50 = 8 and 7.5 µM, respectively, with Poly(dI-dC) as the substrate), as well as CpG DNA methylase M. Sss I (IC 50 = 13.5 and 16 µM, respectively, with Poly(dI-dC) as the substrate and 75 or 150 nM AdoMet) of mycoplasma Spiroplasma sp |
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