PDGFRβ/RAF Kinase Inhibitor - Calbiochem

• Supplier: EMD Millipore
• Catalog: 521238
• Formula: C₂₀H₁₆F₃N₇OS
• Purity: ≥95% by HPLC
• Description: An orally bioavailable amino-triazole compound that is shown to bind to the inactive conformations of both PDGFRβ and Raf kinases (allosteric, Type II inh), and acts as a potent inhibitor of Flt3, Kit, PDGFRα and PDGFRβ (K d = 52, 170, 300 and 520 nM, respectively) with selectivity over B-Raf, p38α, FGFR2 and VEGFR2 (K d > 10 µM) in a multi-kinase panel

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