Geldanamycin
| Name | Geldanamycin |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 9843 |
| Prices | $259.00 |
| Sizes | 600 µg |
| Formula | C29H40N2O9 |
| Molecular Weight | 560.64 g/mol |
| Purity | >99% |
| Description | Geldanamycin (GA) is a naturally existing HSP90 inhibitor that belongs to the benzoquinone ansamycin family. GA binds to the amino terminal ATP-binding pocket of HSP90 and inhibits ATP binding and hydrolysis. HSP90 is a chaperone interacting with a wide variety of important target proteins for cell signaling and regulation during tumorgenesis (1,2). The binding of GA to HSP90 interferes with HSP-mediated target protein folding, leading to target aggregation and degradation (1-3). GA and its synthetic derivatives show higher affinity to HSP90 in tumor cells as compared to normal tissues and constitute a class of protential antitumor drugs (2-3). |
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