Gö6976
| Name | Gö6976 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 12060 |
| Prices | $169.00 |
| Sizes | 500 µg |
| Formula | C24H18N4O |
| Molecular Weight | 378.43 g/mol |
| Purity | >99% |
| Description | Gö6976 is an ATP-competitive PKC inhibitor specific for Ca 2+ -dependent PKCα (IC 50 = 2.3 nM) and PKCβ1 (IC 50 = 6.2 nM) isozymes (1). It is also a potent inhibitor of PKD (IC 50 = 20 nM) (2). Researchers have demonstrated that Gö6976 blocks JNK activation (3-5) and inhibits PKCα-mediated, TPA-stimulated phosphorylation of CREB at Ser133 (6,7). Gö6976 is also an effective inhibitor of the tyrosine kinases Jak2 and FLT3 (8), as well as TrkA and TrkB (9). |
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Product images
Western blot analysis of extracts from Jurkat cells, serum-starved overnight and untreated or treated with TPA #4174 (100 nM, 15 min) either with or without Gö6976 pretreatment (1 hr) at the indicated concentrations, using Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb #4668 (upper) or SAPK/JNK (56G8) Rabbit mAb #9258 (lower).
Chemical Structure of Gö6976.