Ionomycin, Calcium Salt

Name Ionomycin, Calcium Salt
Supplier Cell Signaling Technology
Catalog 9995
Prices $209.00
Sizes 2.5 mg
Formula C41H70O9•Ca2+
Molecular Weight 747.1 g/mol
Purity >99%
Description Ionomycin is a potent and selective calcium ionophore agent (1,2). The molecule acts as a motile Ca 2+ carrier and enhances Ca 2+ influx by direct stimulation of store-regulated cation entry across biological membranes (3). At the micromolar level, ionomycin can activate Ca 2+ /Calmodulin dependent kinase and phosphatase to stimulate gene expression (4). In human T cells, ionomycin induces hydrolysis of phosphoinositides and activates PKC to mediate T cell activation (5). Ionomycin treatment of human B cells induces the activation of calcium-dependent endonuclease and results in apoptosis (6). Ionomycin treatment of bovine aortic endothelial cells (BAECs) induces rapid dephosphorylation of eNOS at Thr495 and mediates eNOS activation (7).
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