Nocodazole

• Supplier: Cell Signaling Technology
• Catalog: 2190
• Prices: $89.00
• Sizes: 10 mg
• Formula: C14H11N3O3S
• Molecular Weight: 301.3 g/mol
• Purity: >97%
• Description: Nocodazole is an anti-neoplastic agent that reversibly interferes with the polymerization of microtubules (1). Widely-used as a cell cycle synchronizing agent in cell biology labs to induce mitotic arrest, investigators have demonstrated that high concentrations of nocodazole induce microtubule depolymerization, whereas low concentrations alter spindle microtubule dynamics, but microtubules do not depolymerize (2-4). Recent research studies have demonstrated nocodazole to be a common inhibitor of various cancer-related kinases, including: ABL, c-KIT, BRAF, MEK1, MEK2, and MET (5).

Product images

Western blot analysis of extracts from HeLa cells untreated (-) or treated with Nocodazole (0.1 μg/ml, 18 hr; +) or λ phosphatase (+), using Phospho-Histone H3 (Ser10) (D2C8) XP ® Rabbit mAb #3377 (upper) or Histone H3 Antibody #9715 (lower).

Western blot analysis of extracts from HeLa cells, untreated (-) or treated with Nocodazole (0.1 μg/ml, 18 hr; +), using Phospho-NPM (Ser4) (D19C1) XP ® Rabbit mAb #3520 (upper) or NPM Antibody #3542 (lower).

Chemical structure of nocodazole.