PD184352
| Name | PD184352 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 12147 |
| Prices | $99.00 |
| Sizes | 5 mg |
| Formula | C17H14ClF2IN2O22 |
| Molecular Weight | 478.66 g/mol |
| Description | PD184352 (CI-1040) is a highly potent and selective noncompetitive MEK inhibitor with an IC 50 of 17 nM for MEK1 (1). Treatment of cells with PD184352 leads to suppression of MAPK activation (1-4) and potently inhibits the proliferation of cells harboring the B-Raf mutation V600E (2,3). Researchers have shown that PD184352 effectively inhibits MEK5, although not as potently as MEK1 (4). |
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Product images
Western blot analysis of extracts from HeLa cells, serum-starved overnight and untreated or treated with TPA #4174 (200 nM, 20 min) either with or without PD184352 pretreatment (1 hr) at the indicated concentrations, using Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP ® Rabbit mAb #4370 (upper) or p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695 (lower).
Chemical structure of PD184352.