PDBu (Phorbol 12,13-Dibutyrate)
| Name | PDBu (Phorbol 12,13-Dibutyrate) |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 12808 |
| Prices | $98.00 |
| Sizes | 1 mg |
| Formula | C28H40O8 |
| Molecular Weight | 504.61 g/mol |
| Purity | >99% |
| Description | Phorbol 12, 13-Dibutyrate (PDBu) is a phorbol ester and a potent activator of protein kinase C (PKC). Frequently used in cancer research, PDBu is widely characterized to promote tumors in a variety of tissue types (1,2). PDBu treatment of cells can lead to activation of downstream PKC targets such as p44/42 MAPK and MARCKS (3-5). Although less potent than TPA, research has shown PDBu elicits less nonspecific binding (6,7) and is less hydrophobic allowing for easy wash out from cells in tissue culture (8). |
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Product images
Western blot analysis of extracts from HeLa cells serum-starved overnight, and untreated (-) or treated with PDBu (15 min; +) at the indicated concentrations, using Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP ® Rabbit mAb #4370 (upper) or p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695 (lower).
Chemical structure of PDBu.