PKC412
| Name | PKC412 |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 9493 |
| Prices | $179.00 |
| Sizes | 1 mg |
| Formula | C35H30N4O4 |
| Molecular Weight | 570.65 g/mol |
| Purity | >99% |
| Description | The staurosporine analog, PKC412, inhibits a variety of serine/threonine and tyrosine kinases including PKC (IC 50 = 50 nM), cyclic AMP-dependent protein kinase (IC 50 = 2.4 µM), S6 kinase (IC 50 = 5.0 µM), and EGFR (epidermal growth factor receptor) tyrosine kinase activity (IC 50 = 3.0 µM) (1). PKC412 has also demonstrated stong inhibitory effects on FLT3, which causes G1 cell cycle arrest and apoptosis (2). |
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Product images
Western blot analysis of extracts from Jurkat cells, untreated or treated with Calyculin A #9902 (50 nM, 20 min) with or without pre-treatment with PKC412 (24 hr) for the indicated concentrations, using Phospho-(Ser) PKC Substrate Antibody #2261 (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower).
Western blot analysis of extracts from SEM cells, untreated (-) or treated with PKC412 (1 μM, 24 hr; +), using Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb #3464 (upper) and FLT3 (8F2) Rabbit mAb #3462 (lower).
Chemical structure of PKC412.