Roscovitine
| Name | Roscovitine |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 9885 |
| Prices | $49.00 |
| Sizes | 1 mg |
| Formula | C19H28N6O |
| Molecular Weight | 354.46 g/mol |
| Purity | >99% |
| Description | Roscovitine is a cell permeable reversible selective inhibitor of cyclin-dependent kinases CDK1 (cdc2), CDK2 and CDK5 (1). A purine analog, this drug competes for the binding site of ATP in the catalytic cleft. Treatment of cultured cells with roscovitine can cause cell cycle arrest or apoptosis (1-4). The IC 50 for cdc2 activity is 0.65 μM in vitro (1). |
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Product images
Western blot analysis of extracts from HeLa cells treated with Roscovitine (20 μM) for the indicated times using Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb #2325 (left) or Phospho-(Ser) CDKs Substrate Antibody #2324 (right).
Western blot analysis of extracts from HeLa cells treated with Roscovitine (20 μM) for the indicated times using an antibody to Rb.
Structure of Roscovitine