GSK2578215A

• Supplier: R&D Systems
• Catalog: 4629
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1285515-21-0
• Chemical Name: 5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
• Formula: C24H18FN3O2
• Molecular Weight: 399.42
• Purity: >99%

Product References

Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease - Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease

Perera G, Ranola M, Rowe DB, Halliday GM, Dzamko N. Sci Rep. 2016 Aug 9;6:31391.

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein - LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein

Belluzzi E, Gonnelli A, Cirnaru MD, Marte A, Plotegher N, Russo I, Civiero L, Cogo S, Carrion MP, Franchin C, Arrigoni G, Beltramini M, Bubacco L, Onofri F, Piccoli G, Greggio E. Mol Neurodegener. 2016 Jan 13;11:1.

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces - Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces

Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W. Mol Brain. 2015 Sep 18;8:54.

Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates - Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates

Russo I, Berti G, Plotegher N, Bernardo G, Filograna R, Bubacco L, Greggio E. J Neuroinflammation. 2015 Dec 9;12:230.

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: - The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells:

Saez-Atienzar S, Bonet-Ponce L, Blesa JR, Romero FJ, Murphy MP, Jordan J, Galindo MF. Cell Death Dis. 2014 Aug 14;5:e1368.

Inhibition of LRRK2 kinase activity stimulates macroautophagy. - Inhibition of LRRK2 kinase activity stimulates macroautophagy.

Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MP, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA. Biochim Biophys Acta. 2013 Dec;1833(12):2900-10. doi: