A 779

• Supplier: Tocris Bioscience
• Catalog: 1701
• Prices: $79.00
• Sizes: 5 mg
• Function Type: Antagonist
• Cas Number: 159432-28-7
• Formula: C39H60N12O11
• Molecular Weight: 872.98
• Description: Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT 1 or AT 2 receptors at a concentration of 1 μ M. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

Product References

TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 - TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1

Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, Chandran P, Gomtsyan A, Brown B, Bayburt EK, Marsh K, Bianchi B, McDonald H, Niforatos W, Neelands TR, Moreland RB, Decker MW, Lee CH, Sullivan JP, Faltynek CR. J Neurosci. 2006 Sep 13;26(37):9385-93.

[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, - [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel,

Bianchi BR, El Kouhen R, Neelands TR, Lee CH, Gomtsyan A, Raja SN, Vaidyanathan SN, Surber B, McDonald HA, Surowy CS, Faltynek CR, Moreland RB, Jarvis MF, Puttfarcken PS. J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. Epub 2007 Jul 27.