A 804598

• Supplier: Tocris Bioscience
• Catalog: 2341
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1125758-85-1
• Chemical Name: N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
• Formula: C19H17N5
• Molecular Weight: 315.37
• Purity: >99 %
• Description: Potent, competitive P2X 7 receptor antagonist (IC 50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X 7 receptors respectively). Selective for P2X 7 receptors (IC 50 > 5-10 μ M for a wide array of cell surface receptors and ion channels). Binds with high affinity (K i app = 2.4 nM for rat P2X 7 receptors).

Product References

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a - [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a

Donnelly-Roberts DL, Namovic MT, Surber B, Vaidyanathan SX, Perez-Medrano A, Wang Y, Carroll WA, Jarvis MF. Neuropharmacology. 2009 Jan;56(1):223-9.

Receptor localization, native tissue binding and ex vivo occupancy for centrally - Receptor localization, native tissue binding and ex vivo occupancy for centrally

Able SL, Fish RL, Bye H, Booth L, Logan YR, Nathaniel C, Hayter P, Katugampola SD. Br J Pharmacol. 2011 Jan;162(2):405-14.