AG 490

• Supplier: Tocris Bioscience
• Catalog: 0493
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 133550-30-8
• Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
• Formula: C17H14N2O3
• Molecular Weight: 294.31
• Purity: >99 %
• Description: Selective inhibitor of EGF receptor tyrosine kinase (IC 50 values are 2 and 13.5 μ M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .

Product References

Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile - Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile

Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A. J Med Chem. 1991 Jun;34(6):1896-907.

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. - Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.

Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM. Nature. 1996 Feb 15;379(6566):645-8.

JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the - JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the

Wang LH, Kirken RA, Erwin RA, Yu CR, Farrar WL. J Immunol. 1999 Apr 1;162(7):3897-904.

The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude - The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude

Abe M, Funakoshi-Tago M, Tago K, Kamishimoto J, Aizu-Yokota E, Sonoda Y, Kasahara T. Int Immunopharmacol. 2009 Jul;9(7-8):870-7.