AG 494

• Supplier: Tocris Bioscience
• Catalog: 0414
• Prices: $125.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 133550-35-3
• Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
• Formula: C16H12N2O3
• Molecular Weight: 280.28
• Description: Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).

Product References

Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile - Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile

Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A. J Med Chem. 1991 Jun;34(6):1896-907.

Tyrphostins that suppress the growth of human papilloma virus 16-immortalized - Tyrphostins that suppress the growth of human papilloma virus 16-immortalized

Ben-Bassat H, Rosenbaum-Mitrani S, Hartzstark Z, Levitzki R, Chaouat M, Shlomai Z, Klein BY, Kleinberger-Doron N, Gazit A, Tsvieli R, Levitzki A. J Pharmacol Exp Ther. 1999 Sep;290(3):1442-57.

Cross-talk between the calcium-sensing receptor and the epidermal growth factor - Cross-talk between the calcium-sensing receptor and the epidermal growth factor

Tomlins SA, Bolllinger N, Creim J, Rodland KD. Exp Cell Res. 2005 Aug 15;308(2):439-45.