AG 555

• Supplier: Tocris Bioscience
• Catalog: 0619
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 133550-34-2
• Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide
• Formula: C19H18N2O3
• Molecular Weight: 322.36
• Purity: >99 %
• Description: Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).

Product References

Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile - Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile

Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A. J Med Chem. 1991 Jun;34(6):1896-907.

Tyrosine kinase inhibition: an approach to drug development. - Tyrosine kinase inhibition: an approach to drug development.

Levitzki A, Gazit A. Science. 1995 Mar 24;267(5205):1782-8.

Tyrphostins that suppress the growth of human papilloma virus 16-immortalized - Tyrphostins that suppress the growth of human papilloma virus 16-immortalized

Ben-Bassat H, Rosenbaum-Mitrani S, Hartzstark Z, Levitzki R, Chaouat M, Shlomai Z, Klein BY, Kleinberger-Doron N, Gazit A, Tsvieli R, Levitzki A. J Pharmacol Exp Ther. 1999 Sep;290(3):1442-57.