AG 825

Name AG 825
Supplier Tocris Bioscience
Catalog 0616
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 149092-50-2
Chemical Name (E)-3-[3-[2-Benzothiazolythio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
Formula C19H15N3O3S2
Molecular Weight 397.47
Description Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 μ M at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
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Product References

Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted - Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted

Gazit A, Osherov N, Posner I, Bar-Sinai A, Gilon C, Levitzki A. J Med Chem. 1993 Nov 12;36(23):3556-64.

Selective inhibition of the epidermal growth factor and HER2/neu receptors by - Selective inhibition of the epidermal growth factor and HER2/neu receptors by

Osherov N, Gazit A, Gilon C, Levitzki A. J Biol Chem. 1993 May 25;268(15):11134-42.

Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent - Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent

Murillo H, Schmidt LJ, Tindall DJ. Cancer Res. 2001 Oct 15;61(20):7408-12.