AG 879

• Supplier: Tocris Bioscience
• Catalog: 1555
• Prices: $175.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 148741-30-4
• Chemical Name: (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide
• Formula: C18H24N2OS
• Molecular Weight: 316.46
• Purity: >99 %
• Description: Inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC 50 values are approximately 1 μ M for both).

Product References

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses - The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses

He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, Kawakami, Hsieh CY, Kung HJ, Lessene G, Baell J, Levitzki A, Maruta H. Cancer Biol Ther. 2004 Jan;3(1):96-101. Epub 2004 Jan 29.

Role of nerve growth factor and its receptors in non-nervous cancer growth: - Role of nerve growth factor and its receptors in non-nervous cancer growth:

Rende M, Pistilli A, Stabile AM, Terenzi A, Cattaneo A, Ugolini G, Sanna P. Anticancer Drugs. 2006 Sep;17(8):929-41.