AG 99

• Supplier: Tocris Bioscience
• Catalog: 2617
• Prices: $125.00, $525.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 122520-85-8
• Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
• Formula: C10H8N2O3
• Molecular Weight: 204.18
• Purity: >99 %
• Description: Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .

Product References

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase - Tyrphostins I: synthesis and biological activity of protein tyrosine kinase

Gazit A, Yaish P, Gilon C, Levitzki A. J Med Chem. 1989 Oct;32(10):2344-52.

Tyrphostins as molecular tools and potential antiproliferative drugs. - Tyrphostins as molecular tools and potential antiproliferative drugs.

Levitzki A, Gilon C. Trends Pharmacol Sci. 1991 May;12(5):171-4.

Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors - Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors

Gazit A, Osherov N, Gilon C, Levitzki A. J Med Chem. 1996 Dec 6;39(25):4905-11.

Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for - Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for

Yamamoto N, Mammadova G, Song RX, Fukami Y, Sato K. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33. Epub 2006 Oct 24.