ω -Agatoxin IVA

Name ω -Agatoxin IVA
Supplier Tocris Bioscience
Catalog 0497
Prices $199.00
Sizes 10 µg
Function Type Blocker
Cas Number 145017-83-0
Formula C217H360N68O60S10
Molecular Weight 5202.25
Description Selective blocker of P-type calcium channels (IC 50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.
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Product References

P-type calcium channels blocked by the spider toxin omega-Aga-IVA. - P-type calcium channels blocked by the spider toxin omega-Aga-IVA.

Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, Adams ME. Nature. 1992 Feb 27;355(6363):827-9.

Calcium channels coupled to glutamate release identified by omega-Aga-IVA. - Calcium channels coupled to glutamate release identified by omega-Aga-IVA.

Turner TJ, Adams ME, Dunlap K. Science. 1992 Oct 9;258(5080):310-3.

Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type - Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type

Bourinet E, Soong TW, Sutton K, Slaymaker S, Mathews E, Monteil A, Zamponi GW, Nargeot J, Snutch TP. Nat Neurosci. 1999 May;2(5):407-15.

Protease treatment of cerebellar purkinje cells renders omega-agatoxin - Protease treatment of cerebellar purkinje cells renders omega-agatoxin

Tringham EW, Dupere JR, Payne CE, Usowicz MM. J Pharmacol Exp Ther. 2008 Feb;324(2):806-14. Epub 2007 Nov 1.