AK 7

• Supplier: Tocris Bioscience
• Catalog: 0678
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 420831-40-9
• Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
• Formula: C19H21BrN2O3S
• Molecular Weight: 437.35
• Purity: >98 %
• Description: Selective SIRT2 inhibitor (IC 50 = 15.5 μ M); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Product References

A brain-permeable small molecule reduces neuronal cholesterol by inhibiting - A brain-permeable small molecule reduces neuronal cholesterol by inhibiting

Taylor DM, Balabadra U, Xiang Z, Woodman B, Meade S, Amore A, Maxwell MM, Reeves S, Bates GP, Luthi-Carter R, Lowden PA, Kazantsev AG. ACS Chem Biol. 2011 Jun 17;6(6):540-6.

The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse - The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse

Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG. Cell Rep. 2012 Dec 27;2(6):1492-7.