AL 8697

• Supplier: Tocris Bioscience
• Catalog: 2422
• Prices: $245.00, $1,005.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1057394-06-5
• Chemical Name: N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide
• Formula: C21H21F3N4O
• Molecular Weight: 402.41
• Purity: >98 %
• Description: Potent and selective p38 α inhibitor (IC 50 = 6 nM). Exhibits 14-fold greater inhibition of p38 α compared to p38 β ; also displays 300-fold selectivity for p38 α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.

Product References

Novel triazolopyridylbenzamides as potent and selective p38alpha inhibitors. - Novel triazolopyridylbenzamides as potent and selective p38alpha inhibitors.

Aiguade J, Balague C, Carranco I, Caturla F, Dominguez M, Eastwood P, Esteve C, Gonzalez J, Lumeras W, Orellana A, Preciado S, Roca R, Vidal L, Vidal B. Bioorg Med Chem Lett. 2012 May 15;22(10):3431-6.

Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat - Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat

Balague C, Pont M, Prats N, Godessart N. Br J Pharmacol. 2012 Jun;166(4):1320-32.