Alda 1

• Supplier: Tocris Bioscience
• Catalog: 4490
• Prices: $75.00, $315.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 349438-38-6
• Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
• Formula: C15H11Cl2NO3
• Molecular Weight: 324.16
• Purity: >99 %
• Description: Activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.

Product References

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. - Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Science. 2008 Sep 12;321(5895):1493-5.

Characterization of the East Asian variant of aldehyde dehydrogenase-2: - Characterization of the East Asian variant of aldehyde dehydrogenase-2:

Beretta M, Gorren AC, Wenzl MV, Weis R, Russwurm M, Koesling D, Schmidt K, Mayer B. J Biol Chem. 2010 Jan 8;285(2):943-52.