Alexidine dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4005
• Prices: $105.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 1715-30-6
• Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamidedihydrochloride
• Formula: C26H56N10.2HCl
• Molecular Weight: 581.71
• Description: Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC 50 = 1.08 μ M in vitro ). Stimulates increased insulin secretion by β -cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo .

Product References

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer - Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer

Yip KW, Ito E, Mao X, Au PY, Hedley DW, Mocanu JD, Bastianutto C, Schimmer A, Liu FF. Mol Cancer Ther. 2006 Sep;5(9):2234-40.

Pharmacological targeting of the mitochondrial phosphatase PTPMT1. - Pharmacological targeting of the mitochondrial phosphatase PTPMT1.

Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ. J Pharmacol Exp Ther. 2010 May;333(2):584-92.

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular - Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular

Liu X, Zheng H, Yu WM, Cooper TM, Bunting KD, Qu CK. Blood. 2015 Mar 5;125(10):1562-5.