| Name | AMG 837 hemicalcium salt |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3920 |
| Prices | $189.00, $795.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 1291087-14-3 |
| Chemical Name | (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoicacidhemicalciumsalt |
| Formula | C26H20F3O3.½Ca |
| Molecular Weight | 457.47 |
| Purity | >98 % |
| Description | Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC 50 values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo . Antidiabetic. |
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Doherty EM, Fotsch C, Bo Y, Chakrabarti PP, Chen N, Gavva N, Han N, Kelly MG, Kincaid J, Klionsky L, Liu Q, Ognyanov VI, Tamir R, Wang X, Zhu J, Norman MH, Treanor JJ. J Med Chem. 2005 Jan 13;48(1):71-90.
Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F, Doherty EM, Norman MH, Wild KD, Bannon AW, Louis JC, Treanor JJ. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84. Epub 2004 Dec 22.