D-AP5

• Supplier: Tocris Bioscience
• Catalog: 3693
• Prices: $75.00, $155.00, $645.00, $875.00
• Sizes: 1 mg, 10 mg, 50 mg, 100 mg
• Function Type: Antagonist
• Cas Number: 79055-68-8
• Chemical Name: D-(-)-2-Amino-5-phosphonopentanoicacid
• Formula: C5H12NO5P
• Molecular Weight: 197.13
• Purity: >99 %
• Description: Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer, L-AP5 (Cat. No. 0107). Also available as part of the Mixed NMDA Receptor Tocriset™ or as a mixed isomer DL-AP5 (Cat. No. 0105).

Product References

Actions of D and L forms of 2-amino-5-phosphonovalerate and - Actions of D and L forms of 2-amino-5-phosphonovalerate and

Davies J, Watkins JC. Brain Res. 1982 Mar 11;235(2):378-86.

The effects of a series of omega-phosphonic alpha-carboxylic amino acids on - The effects of a series of omega-phosphonic alpha-carboxylic amino acids on

Evans RH, Francis AA, Jones AW, Smith DA, Watkins JC. Br J Pharmacol. 1982 Jan;75(1):65-75.

Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) - Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6)

Schulte MK, Roon RJ, Chalmers DJ, Sunter DC, Koerner JF. Brain Res. 1994 Jun 27;649(1-2):203-7.