AR-C 69931 tetrasodium salt

• Supplier: Tocris Bioscience
• Catalog: 3321
• Prices: $229.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 163706-36-3
• Chemical Name: N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphatetetrasodiumsalt
• Formula: C17H21Cl2F3N5Na4O12P3S2
• Molecular Weight: 864.29
• Purity: >98 %
• Description: Highly potent P2Y 12 antagonist (IC 50 = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo . Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo .

Product References

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated - The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated

Ovens MJ, Manoharan C, Wilson MC, Murray CM, Halestrap AP. Biochem J. 2010 Oct 15;431(2):217-25.

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 - AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2

Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP. Biochem J. 2010 Jan 15;425(3):523-30.

Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and - Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and

Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL. Cancer Res. 2014 Feb 1;74(3):908-20.