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AS 252424

Name AS 252424
Supplier Tocris Bioscience
Catalog 5430
Prices $225.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 900515-16-4
Chemical Name 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Formula C14H8FNO4S
Molecular Weight 305.28
Purity >98 %
Description Potent and selective inhibitor of PI 3-kinase γ (IC 50 values are 33 and 935 nM for PI 3-K γ and PI 3-K α respectively).
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Product References

Sequential activation of class IB and class IA PI3K is important for the primed - Sequential activation of class IB and class IA PI3K is important for the primed

Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT. Blood. 2005 Aug 15;106(4):1432-40. Epub 2005 May 5.

Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors - Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors

Pomel V, Klicic J, Covini D, Church DD, Shaw JP, Roulin K, Burgat-Charvillon F, Valognes D, Camps M, Chabert C, Gillieron C, Francon B, Perrin D, Leroy D, Gretener D, Nichols A, Vitte PA, Carboni S, Rommel C, Schwarz MK, Ruckle T. J Med Chem. 2006 Jun 29;49(13):3857-71.



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