| Name | ATC 0175 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3359 |
| Prices | $205.00, $845.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 510733-97-8 |
| Chemical Name | N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride |
| Formula | C23H25F2N5O.HCl |
| Molecular Weight | 461.94 |
| Purity | >98 % |
| Description | Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH 1 ) antagonist (IC 50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT 2B and 5-HT 1A receptors (IC 50 values are 9.66 and 16.9 nM respectively). |
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Chaki S, Funakoshi T, Hirota-Okuno S, Nishiguchi M, Shimazaki T, Iijima M, Grottick AJ, Kanuma K, Omodera K, Sekiguchi Y, Okuyama S, Tran TA, Semple G, Thomsen W. J Pharmacol Exp Ther. 2005 May;313(2):831-9. Epub 2005 Jan 26.
Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. CNS Drug Rev. 2005 Winter;11(4):341-52.