ATI 2341

• Supplier: Tocris Bioscience
• Catalog: 0393
• Prices: $199.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 1337878-62-2
• Formula: C104H178N26O25S2
• Molecular Weight: 2256.82
• Description: CXCR4 allosteric agonist (EC 50 = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro . Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo . Exhibits biased signaling towards G i proteins over G 13 and β -arrestin.

Product References

Highly selective and specific antagonism of central and peripheral alpha - Highly selective and specific antagonism of central and peripheral alpha

Virtanen R, Savola JM, Saano V. Arch Int Pharmacodyn Ther. 1989 Jan-Feb;297:190-204.

An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery - An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery

Puurunen K, Jolkkonen J, Sirvio J, Haapalinna A, Sivenius J. Neuropharmacology. 2001 Mar;40(4):597-606.

Alpha2A adrenergic receptor activation inhibits epileptiform activity in the rat - Alpha2A adrenergic receptor activation inhibits epileptiform activity in the rat

Jurgens CW, Hammad HM, Lichter JA, Boese SJ, Nelson BW, Goldenstein BL, Davis KL, Xu K, Hillman KL, Porter JE, Doze VA. Mol Pharmacol. 2007 Jun;71(6):1572-81. Epub 2007 Mar 6.