Atiprimod dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2937
• Prices: $209.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 130065-61-1
• Chemical Name: N,N-Diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanaminedihydrochloride
• Formula: C22H44N2.2HCl
• Molecular Weight: 409.52
• Description: JAK2 inhibitor (IC 50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2 V617F mutation.

Product References

Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the - Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the

Manshouri T, Estrov Z, Quintas-Cardama A, Burger J, Zhang Y, Livun A, Knez L, Harris D, Creighton CJ, Kantarjian HM, Verstovsek S. Cancer Res. 2011 Jun 1;71(11):3831-40.

Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. - Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor.

Quintas-Cardama A, Manshouri T, Estrov Z, Harris D, Zhang Y, Gaikwad A, Kantarjian HM, Verstovsek S. Invest New Drugs. 2011 Oct;29(5):818-26.