ATPA

• Supplier: Tocris Bioscience
• Catalog: 3245
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 140158-50-5
• Chemical Name: (RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoicacid
• Formula: C10H16N2O4
• Molecular Weight: 228.25
• Purity: >98 %
• Description: A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .

Product References

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. - A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission.

Clarke VR, Ballyk BA, Hoo KH, Mandelzys A, Pellizzari A, Bath CP, Thomas J, Sharpe EF, Davies CH, Ornstein PL, Schoepp DD, Kamboj RK, Collingridge GL, Lodge D, Bleakman D. Nature. 1997 Oct 9;389(6651):599-603.

AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of - AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of

Matzen L, Engesgaard A, Ebert B, Didriksen M, Frolund B, Krogsgaard-Larsen P, Jaroszewski JW. J Med Chem. 1997 Feb 14;40(4):520-7.

Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical - Excitotoxic injury profiles of low-affinity kainate receptor agonists in cortical

Moldrich RX, Cheung NS, Pascoe CJ, Beart PM. Eur J Pharmacol. 1999 Aug 6;378(2):R1-3.