Auranofin

• Supplier: Tocris Bioscience
• Catalog: 1906
• Prices: $69.00, $279.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 34031-32-8
• Chemical Name: 1-Thio-β-D-glucopyranosatotriethylphosphinegold-2,3,4,6-tetraacetate
• Formula: C20H34AuO9PS
• Molecular Weight: 678.48
• Description: Inhibitor of thioredoxin reductase (TrxR) (IC 50 = 20 nM; K i = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Thought to induce the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Also exhibits anti-inflammatory and immunosuppressive activities; inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.

Product References

Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase - Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase

Betts WH, Hurst NP, Murphy GA, Cleland LG. Biochem Pharmacol. 1990 Apr 1;39(7):1233-7.

Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state - Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state

Gromer S, Arscott LD, Williams CH Jr, Schirmer RH, Becker K. J Biol Chem. 1998 Aug 7;273(32):20096-101.

Induction of mitochondrial permeability transition by auranofin, a - Induction of mitochondrial permeability transition by auranofin, a

Rigobello MP, Scutari G, Boscolo R, Bindoli A. Br J Pharmacol. 2002 Aug;136(8):1162-8.

Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1 - Auranofin blocks interleukin-6 signalling by inhibiting phosphorylation of JAK1

Kim NH, Lee MY, Park SJ, Choi JS, Oh MK, Kim IS. Immunology. 2007 Dec;122(4):607-14. Epub 2007 Jul 20.