AX 15836

Name	AX 15836
Supplier	Tocris Bioscience
Catalog	3126
Prices	$289.00
Sizes	10 mg
Function Type	Inhibitor
Chemical Name	5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Formula	C32H40N8O5S
Molecular Weight	648.78
Purity	>98 %
Description	Potent and selective ERK5 inhibitor (IC 50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (K d = 3,600 nM).
Supplier Page	Shop

Product References

Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an - Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an

Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR, Amundson K, Chen JH, Rewolinski DA, Yamazaki S, Wu EY, McTigue MA, Murray BW, Kania RS, O'Connor P, Shalinsky DR, Bender SL. Clin Cancer Res. 2008 Nov 15;14(22):7272-83.

Modulation of the antitumor activity of metronomic cyclophosphamide by the - Modulation of the antitumor activity of metronomic cyclophosphamide by the

Ma J, Waxman DJ. Mol Cancer Ther. 2008 Jan;7(1):79-89.

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding - Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding

Pemovska T, Johnson E, Kontro M, Repasky GA, Chen J, Wells P, Cronin CN, McTigue M, Kallioniemi O, Porkka K, Murray BW, Wennerberg K. Nature. 2015 Mar 5;519(7541):102-5.