| Name | AZ 10397767 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1487 |
| Prices | $209.00, $879.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 333742-63-5 |
| Chemical Name | 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one |
| Formula | C15H14ClFN4O2S2 |
| Molecular Weight | 400.88 |
| Purity | >98 % |
| Description | Potent CXCR2 antagonist (IC 50 = 1 nM); attenuates oxaliplatin -induced NF- κ B activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. Reduces the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models. Orally bioavailable. |
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