AZ 10606120 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2172
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 607378-18-7
• Chemical Name: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride
• Formula: C25H34N4O2.2HCl
• Molecular Weight: 495.48
• Purity: >98 %
• Description: Potent P2X 7 receptor antagonist (K D values are 1.4 and 19 nM at human and rat P2X 7 receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.

Product References

Direct labelling of the human P2X7 receptor and identification of positive and - Direct labelling of the human P2X7 receptor and identification of positive and

Michel AD, Chambers LJ, Clay WC, Condreay JP, Walter DS, Chessell IP. Br J Pharmacol. 2007 May;151(1):103-14. Epub 2007 Mar 5.

Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. - Agonist potency at P2X7 receptors is modulated by structurally diverse lipids.

Michel AD, Fonfria E. Br J Pharmacol. 2007 Oct;152(4):523-37. Epub 2007 Aug 13.

Negative and positive allosteric modulators of the P2X(7) receptor. - Negative and positive allosteric modulators of the P2X(7) receptor.

Michel AD, Chambers LJ, Walter DS. Br J Pharmacol. 2008 Feb;153(4):737-50. Epub 2007 Dec 10.

Expression of P2X7 receptor increases in vivo tumor growth. - Expression of P2X7 receptor increases in vivo tumor growth.

Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P, Bianchi G, Kroemer G, Pistoia V, Di Virgilio F. Cancer Res. 2012 Jun 15;72(12):2957-69.