AZ 11645373

• Supplier: Tocris Bioscience
• Catalog: 3323
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 227088-94-0
• Chemical Name: 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
• Formula: C24H21N3O5S
• Molecular Weight: 463.51
• Purity: >98 %
• Description: Potent and selective human P2X 7 antagonist (K B values are 5 - 7 and > 10,000 nM at hP2X 7 and rP2X 7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 β release in vitro (K B values are 15 and 92 nM respectively).

Product References

Characterization of a selective and potent antagonist of human P2X(7) receptors, - Characterization of a selective and potent antagonist of human P2X(7) receptors,

Stokes L, Jiang LH, Alcaraz L, Bent J, Bowers K, Fagura M, Furber M, Mortimore M, Lawson M, Theaker J, Laurent C, Braddock M, Surprenant A. Br J Pharmacol. 2006 Dec;149(7):880-7. Epub 2006 Oct 9.

Mechanism of action of species-selective P2X(7) receptor antagonists. - Mechanism of action of species-selective P2X(7) receptor antagonists.

Michel AD, Ng SW, Roman S, Clay WC, Dean DK, Walter DS. Br J Pharmacol. 2009 Apr;156(8):1312-25.