AZ 3146

• Supplier: Tocris Bioscience
• Catalog: 5198
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1124329-14-1
• Chemical Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
• Formula: C24H32N6O3
• Molecular Weight: 452.55
• Purity: >99 %
• Description: Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC 50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Product References

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the - Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the

Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS. J Cell Biol. 2010 Jul 12;190(1):25-34.

A chemical tool box defines mitotic and interphase roles for Mps1 kinase. - A chemical tool box defines mitotic and interphase roles for Mps1 kinase.

Lan W, Cleveland DW. J Cell Biol. 2010 Jul 12;190(1):21-4.

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and - Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. J Cell Biol. 2010 Jul 12;190(1):89-100.