BIX

• Supplier: Tocris Bioscience
• Catalog: 5216
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Inducer
• Cas Number: 101714-41-4
• Chemical Name: 2-(3,4-Dihydroxyphenyl)-2-oxoethylesterthiocyanicacid
• Formula: C9H7NO3S
• Molecular Weight: 209.22
• Purity: >98 %
• Description: BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo . Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo .

Product References

A molecular chaperone inducer protects neurons from ER stress. - A molecular chaperone inducer protects neurons from ER stress.

Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M. Cell Death Differ. 2008 Feb;15(2):364-75. Epub 2007 Nov 30.

Induction of BiP, an ER-resident protein, prevents the neuronal death induced by - Induction of BiP, an ER-resident protein, prevents the neuronal death induced by

Oida Y, Izuta H, Oyagi A, Shimazawa M, Kudo T, Imaizumi K, Hara H. Brain Res. 2008 May 7;1208:217-24.

Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) - Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER)

Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, Sajiki H, Kudo T, Aihara M, Imaizumi K, Araie M, Hara H. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):334-44.