Butabindide oxalate

• Supplier: Tocris Bioscience
• Catalog: 0962
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 185213-03-0
• Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamideoxalate
• Formula: C17H25N3O2.C2H2O4
• Molecular Weight: 393.44
• Purity: >99 %
• Description: Potent, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (K i = 7 nM). Active in vivo (ID 50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Product References

Characterization and inhibition of a cholecystokinin-inactivating serine - Characterization and inhibition of a cholecystokinin-inactivating serine

Rose C, Vargas F, Facchinetti P, Bourgeat P, Bambal RB, Bishop PB, Chan SM, Moore AN, Ganellin CR, Schwartz JC. Nature. 1996 Apr 4;380(6573):403-9.

Characterization and cloning of tripeptidyl peptidase II from the fruit fly, - Characterization and cloning of tripeptidyl peptidase II from the fruit fly,

Renn SC, Tomkinson B, Taghert PH. J Biol Chem. 1998 Jul 24;273(30):19173-82.

Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead - Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead

Ganellin CR, Bishop PB, Bambal RB, Chan SM, Law JK, Marabout B, Luthra PM, Moore AN, Peschard O, Bourgeat P, Rose C, Vargas F, Schwartz JC. J Med Chem. 2000 Feb 24;43(4):664-74.