C 646

• Supplier: Tocris Bioscience
• Catalog: 4123
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 328968-36-1
• Chemical Name: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoicacid
• Formula: C24H19N3O6
• Molecular Weight: 445.42
• Purity: >98 %
• Description: Selective p300/CREB-binding protein (CBP) inhibitor (K i = 400 nM). Selective against six other histone acetyltransferases (HATs). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

Product References

Virtual ligand screening of the p300/CBP histone acetyltransferase: - Virtual ligand screening of the p300/CBP histone acetyltransferase:

Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, Marmorstein R, Mahadevan LC, Alani RM, Cole PA. Chem Biol. 2010 May 28;17(5):471-82.

Butyrate greatly enhances derivation of human induced pluripotent stem cells by - Butyrate greatly enhances derivation of human induced pluripotent stem cells by

Mali P, Chou BK, Yen J, Ye Z, Zou J, Dowey S, Brodsky RA, Ohm JE, Yu W, Baylin SB, Yusa K, Bradley A, Meyers DJ, Mukherjee C, Cole PA, Cheng L. Stem Cells. 2010 Apr;28(4):713-20.

HAT trick: p300, small molecule, inhibitor. - HAT trick: p300, small molecule, inhibitor.

Ott M, Verdin E. Chem Biol. 2010 May 28;17(5):417-8.