Cevimeline hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3536
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 107220-28-0
• Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]hydrochloride
• Formula: C10H17NOS.HCl
• Molecular Weight: 235.77
• Description: Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .

Product References

Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane - Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane

Wanibuchi F, Konishi T, Harada M, Terai M, Hidaka K, Tamura T, Tsukamoto S, Usuda S. Eur J Pharmacol. 1990 Oct 23;187(3):479-86.

(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective - (+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective

Fisher A, Brandeis R, Karton I, Pittel Z, Gurwitz D, Haring R, Sapir M, Levy A, Heldman E. J Pharmacol Exp Ther. 1991 Apr;257(1):392-403.

L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 - L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3

Hargreaves RJ, McKnight AT, Scholey K, Newberry NR, Street LJ, Hutson PH, Semark JE, Harley EA, Patel S, Freedman SB. Br J Pharmacol. 1992 Oct;107(2):494-501.