CGP 35348

• Supplier: Tocris Bioscience
• Catalog: 2966
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 123690-79-9
• Chemical Name: (3-Aminopropyl)(diethoxymethyl)phosphinicacid
• Formula: C8H20NO4P
• Molecular Weight: 225.22
• Description: Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Product References

CGP 35348: a centrally active blocker of GABAB receptors. - CGP 35348: a centrally active blocker of GABAB receptors.

Olpe HR, Karlsson G, Pozza MF, Brugger F, Steinmann M, Van Riezen H, Fagg G, Hall RG, Froestl W, Bittiger H. Eur J Pharmacol. 1990 Oct 2;187(1):27-38.

Intrathecal gamma-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 - Intrathecal gamma-aminobutyric acidB (GABAB) receptor antagonist CGP 35348

Hao JX, Xu XJ, Wiesenfeld-Hallin Z. Neurosci Lett. 1994 Dec 5;182(2):299-302.

Involvement of GABA(B) receptors in convulsant-induced epileptiform activity in - Involvement of GABA(B) receptors in convulsant-induced epileptiform activity in

Sutor B, Luhmann HJ. Eur J Neurosci. 1998 Nov;10(11):3417-27.

GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP - GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP

Staubli U, Scafidi J, Chun D. J Neurosci. 1999 Jun 1;19(11):4609-15.