( S )-CPW 399

• Supplier: Tocris Bioscience
• Catalog: 1645
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 389888-02-2
• Chemical Name: (S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoicacid
• Formula: C10H13N3O4
• Molecular Weight: 239.23
• Purity: >98 %
• Description: Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (K i values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Exhibits potent agonist activity at GluR1 and GluR2 subunit-containing AMPA receptors (EC 50 values are 24.9 and 13.9 μ M respectively) and is excitotoxic in vitro .

Product References

Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative - Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative

Campiani G, Morelli E, Nacci V, Fattorusso C, Ramunno A, Novellino E, Greenwood J, Liljefors T, Griffiths R, Sinclair C, Reavy H, Kristensen AS, Pickering DS, Schousboe A, Cagnotto A, Fumagalli E, Mennini T. J Med Chem. 2001 Dec 20;44(26):4501-4.

Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA - Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA

Sinclair C, Reavy H, Grieve A, Schousboe A, Morelli E, Novellino E, Campiani G, Griffiths R. Neurochem Int. 2003 May;42(6):499-510.

1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors - 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors

Butini S, Pickering DS, Morelli E, Coccone SS, Trotta F, De Angelis M, Guarino E, Fiorini I, Campiani G, Novellino E, Schousboe A, Christensen JK, Gemma S. J Med Chem. 2008 Oct 23;51(20):6614-8.