Flunarizine dihydrochloride blocks L-type Ca2+ currents in Xenopus oocytes. A. Time course of L-type channel (CaV1.2+a2d1+ß1a) activity before and during applications of 10 and 100 µM Flunarizine dihydrochloride (ab141798) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by the horizontal bars. B. Example of superimposed current traces before and during application of 10 and 100 µM Flunarizine dihydrochloride (taken from the experiment described in A).