(-)-Bicuculline methochloride
| Name | (-)-Bicuculline methochloride |
|---|---|
| Supplier | Abcam |
| Catalog | ab120110 |
| Cas Number | 53552-05-9 |
| Pubchem | 56972147 |
| Chemical Name | [S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride |
| Formula | C21H20ClNO6 |
| Molecular Weight | 417.85 |
| Purity | > 99% |
| Description | GABAA antagonist |
| Supplier Page | Shop |
Product images
Current clamp recordings demonstrating that the depolarisation of ependymal cells in response to GABA (200 μM) is partially antagonised by bicuculline (ab120110, 100 μM) in a reversible manner.
Group data for responses to GABA alone or in the presence of bicuculline (bic, ab120110) and/or nipecotic acid (NA).
Product References
mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons - mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons
Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. J Neurosci. 2014 Mar 19;34(12):4309-17.
GABAergic responses of mammalian ependymal cells in the central canal neurogenic - GABAergic responses of mammalian ependymal cells in the central canal neurogenic
Corns LF, Deuchars J, Deuchars SA. Neurosci Lett. 2013 Oct 11;553:57-62.
A continuous high frequency stimulation of the subthalamic nucleus determines a - A continuous high frequency stimulation of the subthalamic nucleus determines a
Ledonne A, Mango D, Bernardi G, Berretta N, Mercuri NB. Exp Neurol. 2012 Jan;233(1):292-302.
Picomolar nitric oxide signals from central neurons recorded using ultrasensitive - Picomolar nitric oxide signals from central neurons recorded using ultrasensitive
Wood KC, Batchelor AM, Bartus K, Harris KL, Garthwaite G, Vernon J, Garthwaite J. J Biol Chem. 2011 Dec 16;286(50):43172-81.
Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic - Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic
Roloff AM, Anderson GR, Martemyanov KA, Thayer SA. J Neurosci. 2010 Feb 24;30(8):3072-81.