| Gene Symbol | SCNN1G |
|---|---|
| Entrez Gene | 6340 |
| Alt Symbol | BESC3, ENaCg, ENaCgamma, PHA1, SCNEG |
| Species | Human |
| Gene Type | protein-coding |
| Description | sodium channel, non voltage gated 1 gamma subunit |
| Other Description | ENaC gamma subunit|amiloride-sensitive epithelial sodium channel gamma subunit|amiloride-sensitive sodium channel gamma-subunit|amiloride-sensitive sodium channel subunit gamma|epithelial Na(+) channel subunit gamma|gamma-ENaC|gamma-NaCH|nonvoltage-gated sodium channel 1 subunit gamma|sodium channel, non-voltage-gated 1, gamma subunit|sodium channel, nonvoltage-gated 1, gamma |
| Swissprots | Q96TD2 Q93026 Q93027 P51170 Q6PCC2 P78437 Q93024 Q93025 Q93023 |
| Accessions | AAC50217 AAC50744 AAC50745 AAC50746 AAC50747 AAC50748 AAC50749 AAC50750 AAC50751 AAC50752 AAC50753 AAC50754 AAC50755 AAC50756 AAC50757 AAC50758 AAC50759 AAC50760 AAC50761 AAK50910 ACS13725 CAB07506 EAW55837 EAW55838 P51170 BC059391 AAH59391 BC069652 AAH69652 DQ402524 ABD72220 L36592 AAA75460 U48936 AAC50737 X87160 CAA60633 NM_001039 NP_001030 |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}. |
| Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:24124190}; Multi-pass membrane protein {ECO:0000269|PubMed:24124190}. Note=Apical membrane of epithelial cells. |
| Tissue Specificity | Expressed in kidney (at protein level). {ECO:0000269|PubMed:22207244}. |
| Top Pathways | Taste transduction, Aldosterone-regulated sodium reabsorption |